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Fine structural changes in the aging mouse thyroid.

H Fujita, S Tamura, T Takano

    Journal of Gerontology
    |January 1, 1980
    PubMed
    Summary
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    Thyroid gland aging in CF1 mice shows larger follicles and increased lysosome density in epithelial cells. Enzyme activity decreases after six months, indicating age-related cellular changes.

    Area of Science:

    • Gerontology
    • Cell Biology
    • Endocrinology

    Background:

    • The aging process affects various organs, including the thyroid gland.
    • Understanding age-related cellular changes is crucial for comprehending thyroid function decline.

    Purpose of the Study:

    • To investigate the morphological and biochemical age-related changes in the thyroid gland of CF1 mice.
    • To characterize the alterations in thyroid follicle structure and lysosomal content with advancing age.

    Main Methods:

    • Morphological analysis of thyroid gland tissues from mice aged 15 days to 24 months.
    • Biochemical assays to measure specific enzyme activities (acid phosphatase, beta-glucuronidase, beta-galactosidase).
    • Quantification of lysosome volumetric density and characteristics within follicular epithelial cells.

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    Main Results:

    • Thyroid follicle diameter increased with age due to fusion, showing greater variability.
    • Volumetric density of lysosomes in follicular epithelial cells increased with age.
    • Lysosomes evolved from small, dense primary lysosomes in young mice to larger, lipid-containing bodies in older mice.
    • Specific activities of acid phosphatase, beta-glucuronidase, and beta-galactosidase decreased after six months of age.

    Conclusions:

    • Thyroid gland aging in mice is characterized by structural changes in follicles and alterations in lysosomal content and enzyme activity.
    • The observed changes suggest a decline in lysosomal hydrolytic capacity and potential accumulation of residual bodies in aged thyroids.
    • These findings contribute to the understanding of thyroid gland aging at a cellular level.