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Radiation-induced large intracranial vessel occlusive vasculopathy
AJR. American Journal of Roentgenology
|January 1, 1980
Summary
Radiation therapy for brain tumors can lead to intracranial vessel occlusion, mimicking accelerated arteriosclerosis. This rare complication requires careful monitoring of patients post-treatment for neurological changes.
Area of Science:
- Neurology
- Oncology
- Vascular Medicine
Background:
- Standard radiation therapy for brain tumors can cause delayed vascular complications.
- Intracranial vessel occlusion is a known, albeit uncommon, sequela of radiotherapy.
Observation:
- Two patients developed large intracranial vessel occlusion following standard radiation therapy for brain tumors.
- Histological examination revealed features consistent with accelerated focal arteriosclerosis.
Findings:
- One case presented atypically with vasculopathy appearing shortly after radiation for ependymoma, showing angiographic signs of diffuse arteritis.
- The second case was more typical, with symptoms 12 years post-radiation for oligodendroglioma, confirmed occlusion of a radiated vessel.
Implications:
- These cases highlight the potential for late-onset intracranial vessel occlusion after radiotherapy.
- Understanding these vascular changes is crucial for managing patients with a history of brain tumor radiation.