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Related Experiment Videos

A transthalamic olfactory pathway to orbitofrontal cortex in the monkey.

H Yarita, M Iino, T Tanabe

    Journal of Neurophysiology
    |January 1, 1980
    PubMed
    Summary

    This study reveals a new olfactory pathway from the olfactory bulb (OB) to the centroposterior orbital cortex (CPOF) via the mediodorsal nucleus (MDmc) of the thalamus, distinct from known pathways.

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    Area of Science:

    • Neuroscience
    • Olfactory System Research
    • Thalamocortical Pathways

    Background:

    • The olfactory system utilizes multiple pathways for information processing.
    • Previous research identified a transhypothalamic olfactory pathway to the lateroposterior orbital cortex (LPOF).
    • The role of the mediodorsal nucleus (MDmc) in olfactory processing remained less understood.

    Purpose of the Study:

    • To investigate a potential transthalamic olfactory pathway.
    • To characterize the electrophysiological properties of neurons in the MDmc and centroposterior orbital cortex (CPOF).
    • To compare the functional characteristics of this new pathway with the established transhypothalamic route.

    Main Methods:

    • Extracellular and intracellular recordings in the MDmc of awake, unanesthetized monkeys.

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  • Stimulation of the olfactory bulb (OB) and orbital cortex (OFC).
  • Application of neurophysiological criteria to identify thalamocortical relay (TCR) neurons.

    • Main Results:

    • Evoked potentials in MDmc were recorded following OB and OFC stimulation, suggesting a transthalamic pathway.
    • 20 out of 58 identified neurons in MDmc were confirmed as TCR neurons activated antidromically by CPOF stimulation.
    • Intracellular recordings revealed specific firing patterns and afterhyperpolarizations in MDmc neurons, indicative of inhibitory input.
    • Responses to eight odors in CPOF and MDmc differed significantly from those in OB, prepyriform-amygdaloid area, and LPOF.

    Conclusions:

    • Electrophysiological evidence supports a novel transthalamic olfactory pathway from OB through MDmc to CPOF.
    • This pathway exhibits distinct functional properties compared to the transhypothalamic olfactory pathway to LPOF.
    • The findings expand our understanding of olfactory information processing in the primate brain.