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Related Experiment Videos

Narcotic-reinforced responding: a rapid evaluation procedure.

J H Woods

    Drug and Alcohol Dependence
    |March 1, 1980
    PubMed
    Summary

    This study shows a fast method to test if drugs reinforce self-injection behavior in rhesus monkeys. Researchers used codeine and found the procedure effective for rapid drug evaluation.

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    Area of Science:

    • Pharmacology
    • Behavioral Neuroscience
    • Drug Addiction Research

    Background:

    • Understanding drug reinforcement is crucial for addiction research.
    • Rhesus monkeys are a common model for studying drug self-administration.
    • Codeine is an opioid analgesic with abuse potential.

    Purpose of the Study:

    • To develop and validate a rapid method for evaluating drug reinforcement.
    • To assess the self-injection behavior of rhesus monkeys under controlled conditions.
    • To determine the efficacy of codeine in maintaining self-administration behavior.

    Main Methods:

    • Rhesus monkeys were trained to self-inject codeine intravenously.
    • A fixed schedule of drug delivery was established.
    • Different doses of codeine and saline were tested in single-session experimental designs.

    Main Results:

    • The self-injection behavior was successfully controlled by the drug delivery schedule.
    • The procedure allowed for rapid comparison of different drug doses.
    • Codeine reliably reinforced the lever-pressing behavior.

    Conclusions:

    • The described procedure offers a rapid and efficient method for evaluating drug reinforcement.
    • This model can be utilized for screening potential reinforcing or aversive properties of novel compounds.
    • Further research can explore variations of this method for different drug classes.

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