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Disease-modifying drugs for progressive rheumatoid arthritis
Mayo Clinic Proceedings
|March 1, 1980
Summary
For rheumatoid arthritis patients unresponsive to basic treatments, stronger drugs like hydroxychloroquine, gold, and azathioprine are considered. This review details their pharmacology, clinical studies, and toxicity profiles.
Area of Science:
- Rheumatology
- Pharmacology
Background:
- Rheumatoid arthritis (RA) often requires advanced therapies when initial treatments fail.
- Salicylates and nonsteroidal anti-inflammatory agents (NSAIDs) are common first-line RA treatments.
Purpose of the Study:
- To review alternative drug options for RA patients refractory to standard therapies.
- To provide an overview of the pharmacology, clinical efficacy, and toxicity of second-line RA medications.
Main Methods:
- Literature review of pharmacological data.
- Analysis of pertinent clinical studies.
- Evaluation of toxicity profiles for specific RA drugs.
Main Results:
- Hydroxychloroquine, gold compounds, penicillamine, azathioprine, and cyclophosphamide are discussed.
- Each agent's pharmacology, mechanism of action, and clinical trial outcomes are presented.
- Key toxicities associated with these stronger RA medications are highlighted.
Conclusions:
- These advanced RA therapies offer alternatives for non-responders.
- Careful consideration of pharmacology and toxicity is crucial for patient management.
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