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Platelet satellitism: experimental studies.

D H McGregor, J W Davis, P I Liu

    Laboratory Investigation; a Journal of Technical Methods and Pathology
    |March 1, 1980
    PubMed
    Summary
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    Platelet satellitism, a rare in vitro phenomenon, involves platelets surrounding leukocytes. Studies reveal it can be induced by various blood factors, often proteins, leading to platelet phagocytosis by neutrophils.

    Area of Science:

    • Hematology
    • Cell Biology
    • Clinical Pathology

    Background:

    • Platelet satellitism (PS) is an uncommon in vitro finding in EDTA-anticoagulated blood.
    • The phenomenon involves platelets rosetting around nonlymphocytic leukocytes and is poorly understood.
    • PS has been reported in patients with diverse clinical conditions.

    Purpose of the Study:

    • To investigate the nature of platelet satellitism.
    • To identify factors in patient blood that induce PS.
    • To elucidate the morphologic sequences and conditions affecting PS.

    Main Methods:

    • Experimental studies using blood from patients with PS.
    • Wet preparation microscopy and electron microscopy (transmission and scanning).
    • Testing effects of time, temperature, anticoagulant, and blood components.

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    Main Results:

    • Electron microscopy showed platelets being phagocytosed by neutrophils.
    • All tested patients exhibited cryofibrinogenemia.
    • Certain blood components from patients induced PS in normal blood, unlike normal components.
    • PS could also be induced in normal blood by specific antihuman antisera and normal platelets.

    Conclusions:

    • Platelet satellitism can result from various factors, often proteins, in conjunction with EDTA.
    • These factors likely alter platelet surface charge, attracting them to neutrophils for phagocytosis.
    • The phenomenon can be induced by factors beyond those specific to patients with PS.