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Related Experiment Videos

Tuberculous bacillemia, hyperpyrexia, and rapid death.

A W Pasculle, S B Kapadia, M Ho

    Archives of Internal Medicine
    |March 1, 1980
    PubMed
    Summary

    A previously healthy man developed fatal hyperpyrexia and organ failure. Disseminated tuberculosis and potential heat stroke were identified, possibly linked to adrenal insufficiency or bacillemia.

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    Authors' reply.

    Hong Kong medical journal = Xianggang yi xue za zhi·2013

    Area of Science:

    • Infectious Diseases
    • Endocrinology
    • Critical Care Medicine

    Background:

    • Tuberculosis (TB) can present with diverse clinical manifestations.
    • Adrenocortical insufficiency can impair thermoregulation.
    • Bacillemia in TB can lead to systemic complications.

    Observation:

    • A previously healthy male presented with severe hyperpyrexia.
    • Rapid progression to multiple organ failure and death occurred.
    • Postmortem findings revealed disseminated tuberculosis with adrenal involvement.

    Findings:

    • Mycobacterium tuberculosis was isolated from blood cultures.
    • Pathological evidence suggested concurrent heat stroke.
    • The patient exhibited unapparent chronic adrenocortical insufficiency.

    Implications:

    • Tuberculous bacillemia may precipitate hyperpyrexia and organ failure.
    • Undiagnosed adrenocortical insufficiency can increase susceptibility to heat-related illness.
    • This case highlights the complex interplay between infection, endocrine dysfunction, and environmental factors.

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