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Related Experiment Videos

Panophthalmitis due to Bacillus cereus.

E J Young, R J Wallace, C D Ericsson

    Archives of Internal Medicine
    |April 1, 1980
    PubMed
    Summary

    Rapid Bacillus cereus eye infections, often linked to intravenous drug use or foreign bodies, led to enucleation in all three patients despite aggressive antibiotic treatment. Isolates showed resistance to common antibiotics but sensitivity to clindamycin and aminoglycosides.

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    Area of Science:

    • Ophthalmology
    • Infectious Diseases
    • Microbiology

    Background:

    • Bacillus cereus is an opportunistic pathogen that can cause severe infections.
    • Ocular infections with Bacillus cereus are rare but can lead to rapid vision loss.

    Observation:

    • Three cases of rapidly progressing panophthalmitis caused by Bacillus cereus are presented.
    • Two cases were associated with intravenous drug abuse, with one linked to contaminated injection paraphernalia.
    • The third case involved a foreign-body injury to the eye.

    Findings:

    • Anterior chamber aspiration identified Bacillus cereus via Gram's stain in one case and bacterial isolation in all three.
    • Despite intravenous and intraocular antibiotic therapy, the infections progressed rapidly, necessitating enucleation in all patients.

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  • Bacillus cereus isolates demonstrated sensitivity to clindamycin hydrochloride hydrate and aminoglycosides, but resistance to penicillins and cephalosporins.

    • Implications:

    • This highlights the aggressive nature of Bacillus cereus panophthalmitis and the challenges in its treatment.
    • Intravenous drug abuse is a significant risk factor for severe ocular infections.
    • Understanding antibiotic sensitivities is crucial for managing Bacillus cereus ocular infections, suggesting clindamycin and aminoglycosides as potential therapeutic options.