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Related Experiment Videos

The subarachnoid space: a review.

D G McLone

    Child'S Brain
    |January 1, 1980
    PubMed
    Summary
    This summary is machine-generated.

    The subarachnoid space shows similar ultrastructure across species, developing in four stages from fetal mesenchymal tissue to adult form. This developmental sequence is key to understanding congenital anomalies.

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    Area of Science:

    • Neuroscience
    • Developmental Biology
    • Comparative Anatomy

    Background:

    • Historical understanding of the subarachnoid space varied due to tissue preservation and species differences.
    • Modern electron microscopy allows for detailed comparative studies.

    Purpose of the Study:

    • To comparatively analyze the subarachnoid space ultrastructure across species.
    • To detail the developmental stages of the pia-arachnoid membranes and subarachnoid space in mice.

    Main Methods:

    • Comparative submicroscopic study of the subarachnoid space in mice, cats, monkeys, and humans.
    • Observation of developmental stages in mouse fetuses and neonates.

    Main Results:

    • Striking similarities in subarachnoid space ultrastructure and distribution were found across studied species.

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  • Mouse subarachnoid space development occurs in four distinct stages, involving vascularization, delineation, vessel ensheathment, and tissue remodeling.
  • Cerebrospinal fluid begins to infiltrate the mesenchymal space around the 13th fetal day, shaping the mature subarachnoid space by the 21st postnatal day.

    • Conclusions:

    • The developmental pathway of the subarachnoid space is conserved across mammals.
    • Understanding this developmental sequence is crucial for investigating the pathogenesis of hydrocephalus and congenital central nervous system anomalies.