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Abstract:
The maturation of the potential for ovulation in man is reviewed in the light of recent data quantitating gonadotropins and gonadal steroids in the prepubertal child. The primary limitations of the hypothalamic-pituitary-gonadal axis are seen as related to feedback control mechanisms. Based on preliminary data obtained in patients with gonadal dysgenesis, a hypothesis which links positive and negative feedback maturation is proposed. The development of full reproductive potential in man is clearly a process which extends over a decade or more.