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Related Experiment Videos

Glycohemoglobin in diabetic pregnancy: a sequential study.

J A Widness, H C Schwartz, C B Kahn

    American Journal of Obstetrics and Gynecology
    |April 15, 1980
    PubMed
    Summary

    Glycohemoglobin (HbA1c) levels change during pregnancy and postpartum, reflecting blood glucose control. These fluctuations, particularly in diabetic women, highlight the importance of monitoring long-term glucose management.

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    Effect of premixed nph and regular insulin on glucose control and health-related quality of life in patients with type 2 diabetes mellitus.

    Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·2004

    Area of Science:

    • Endocrinology
    • Obstetrics
    • Biochemistry

    Background:

    • Glycohemoglobin (HbA1c) reflects long-term glycemic control.
    • Pregnancy is associated with physiological changes affecting glucose metabolism.
    • Monitoring HbA1c is crucial for managing diabetes in pregnancy.

    Purpose of the Study:

    • To investigate sequential changes in HbA1c during pregnancy and postpartum.
    • To compare HbA1c patterns in nondiabetic, insulin-dependent diabetic, and chemically diabetic women.
    • To assess potential alterations in oxygen transport parameters related to HbA1c.

    Main Methods:

    • Sequential assay of HbA1c in 53 pregnant and postpartum women.
    • Categorization into nondiabetic, insulin-dependent diabetic, and chemical diabetes groups.

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  • Measurement of oxygen transport parameters, including P50.

    • Main Results:

    • Nondiabetic women showed a significant decrease in HbA1c from the first to third trimester, returning to baseline postpartum.
    • Insulin-dependent diabetic women exhibited a similar pattern but at significantly higher HbA1c levels.
    • Chemical diabetes patients showed no change over time but had elevated HbA1c during late pregnancy and postpartum.

    Conclusions:

    • Observed HbA1c fluctuations are likely due to changes in long-term blood glucose control.
    • Elevated HbA1c in diabetic pregnancies necessitates careful glycemic management.
    • No significant changes in oxygen transport parameters were observed, except for specific P50 values.