Typing by compatibility in mixed lymphocyte culture using LD-homozygous typing cells

Groups of determinants that produce strong MLC stimulation can be recognized by the use of LD-homozygous typing cells. The importance of these antigens of the main histocompatibility region resides in their involvement in the immune response to thymus-dependent antigens, their role in transplant rejection, and predisposition to disease. Eight specificities are at present recognized, but others are known to exist and can be defined using new typing cells developed in individual laboratories. A collaborative project to study the genetics of the MLC determinants has been initiated by several American investigators.