Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Human and murine tumours: changes in cell surface structures coded by the major histocompatibility complex region.

S Ferrone, M A Pellegrino, G N Callahan

    Journal of Immunogenetics
    |February 1, 1980
    PubMed
    Summary

    Tumor cells exhibit altered surface markers, including changes in human leukocyte antigen (HLA) and H-2 antigens, and acquire new receptors. These immune marker changes are significant in both human and murine cancer systems.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Xenoantisera to human DR antigens: Serological and immunochemical characterization.

    Immunogenetics·2011
    Same author

    Skeletal muscle fibre diversity and the underlying mechanisms.

    Acta physiologica (Oxford, England)·2010
    Same author

    Myosin and actin content of human skeletal muscle fibers following 35 days bed rest.

    Scandinavian journal of medicine & science in sports·2009
    Same author

    Single muscle fiber properties in aging and disuse.

    Scandinavian journal of medicine & science in sports·2009
    Same author

    Effects of resistance training on myosin function studied by the in vitro motility assay in young and older men.

    Journal of applied physiology (Bethesda, Md. : 1985)·2005
    Same author

    Contractile effects of the exchange of cardiac troponin for fast skeletal troponin in rabbit psoas single myofibrils.

    The Journal of physiology·2003

    Area of Science:

    • Immunology
    • Oncology
    • Cell Biology

    Background:

    • Surface markers on tumor cells can undergo alterations affecting immune recognition.
    • Human leukocyte antigen (HLA) and H-2 antigens are critical in immune responses and transplantation.
    • Viral transformations, like with SV40, can induce changes in cell surface properties.

    Purpose of the Study:

    • To investigate serological and structural changes in surface markers of human and murine tumor systems.
    • To compare the reactivity of tumor cell lines and transformed fibroblasts with alloantisera.
    • To identify alterations in H-2 antigens and detect alien HLA antigens in cancer patients.

    Main Methods:

    • Serological analysis using HLA alloantisera.
    • Isolation and structural analysis of H-2 antigens from murine tumor cells.

    Related Experiment Videos

  • Detection of alien HLA-B7 in patient sera.
  • Assays for red blood cell receptor acquisition on transformed cells.

    • Main Results:

    • Nine of twenty-one human tumor cell lines and SV40-transformed fibroblasts showed altered reactivity with HLA alloantisera compared to autologous cells.
    • Structural changes were observed in H-2 antigens from murine tumor cells (6C3HED, TP1422).
    • Alien HLA-B7 was detected in sera from two melanoma patients, and H-2 antigen activity increased in tumor-bearing mice.

    Conclusions:

    • Human and murine tumor systems display significant changes in surface markers involved in immune reactions.
    • Acquisition of new receptors (e.g., for red blood cells) by tumor cells suggests altered cell-cell interactions.
    • These findings highlight the dynamic nature of tumor cell surface antigens and their implications for immune surveillance and therapy.