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Intestinal motility changes in experimental large bowel obstruction.

I D Fraser, R E Condon, W J Schulte

    Surgery
    |June 1, 1980
    PubMed
    Summary
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    Colon obstruction alters smooth muscle electrical activity and contractions, leading to abnormal motility complexes like mass actions, not hyperperistalsis. These mass actions may cause colic and bowel sounds in patients.

    Area of Science:

    • Gastroenterology
    • Physiology
    • Surgical Science

    Background:

    • Colon obstruction is a critical condition affecting gastrointestinal motility.
    • Understanding the physiological changes in colon motility during obstruction is crucial for clinical management.

    Purpose of the Study:

    • To investigate the effects of colon obstruction on smooth muscle electrical activity and contractions in a primate model.
    • To characterize the motility patterns, including peristalsis and mass actions, during the development of colon obstruction.

    Main Methods:

    • Implantation of bipolar electrodes for electrical activity recording and strain gauges for contraction measurement in six rhesus monkeys.
    • Induction of progressive sigmoid colon obstruction over 13 +/- 2 days with daily motility recordings.

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    Main Results:

    • Obstruction led to decreased contraction frequency in the right colon and increased frequency in the proximal left colon.
    • Distention frequency increased proximally, while distal colon activity remained unchanged.
    • Simultaneous mass actions, characterized by non-peristaltic contractions and distentions, appeared and increased with obstruction severity.

    Conclusions:

    • Colon obstruction induces abnormal motility complexes, specifically mass actions, rather than hyperperistalsis.
    • Mass actions are likely responsible for clinical symptoms such as colic and rushing bowel sounds associated with colon obstruction.