Brainstem histopathology following chronic scala tympani implantation in monkeys

Degeneration in brainstem auditory nuclei was studied in monkeys following chronic implantation with scala tympani multielectrode systems. Nauta and Fink/Heimer-stained material from animals with survival times to 16 months were studied. The density and distribution of degeneration in the cochlear nuclei were consistent with observed patterns of spiral ganglion cell degeneration. Transneuronal degeneration was seen up to the level of the inferior colliculus. The density and form of the degeneration material in animals of varying survival times was consistent with the interpretation that a process of continuing degeneration occurred in these implanted ears.