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Updated: Aug 18, 2026

Detection of Invasive Pulmonary Aspergillosis in Haematological Malignancy Patients by using Lateral-flow Technology
08:01

Detection of Invasive Pulmonary Aspergillosis in Haematological Malignancy Patients by using Lateral-flow Technology

Published on: March 22, 2012

[About 35 cases of pleural aspergillosis (author's transl)]

G Pesle, F Triboulet, N Gharbi

    Le Poumon Et Le Coeur
    |January 1, 1980
    PubMed

    Insights

    Pleural aspergillosis is rare, often occurring in post-operative cavities or after pneumothorax. Treatment varies, with surgery often limited, and outcomes can be serious, impacting long-term patient survival.

    Area of Science:

    • Medical Mycology
    • Thoracic Surgery
    • Infectious Diseases

    Background:

    • Pleural aspergillosis is infrequently documented compared to pulmonary aspergillomas.
    • Understanding its occurrence and characteristics is crucial for patient management.

    Purpose of the Study:

    • To analyze the incidence, clinical presentation, and outcomes of pleural aspergillosis.
    • To evaluate therapeutic strategies and their effectiveness in managing this condition.

    Main Methods:

    • Retrospective analysis of 36 cases with pleural aspergillosis.
    • Review of patient history, diagnostic findings, treatment modalities, and outcomes.

    Main Results:

    • Pleural aspergillosis was observed in 36 patients, often associated with post-pulmonary exeresis cavities (24 cases) or therapeutic pneumothorax (11 cases).
    • Aspergillomas and pyothoraxes were the most common forms; associated pulmonary or bronchial involvement was noted.
    • Diagnosis varied from symptomatic presentation to radiological findings, hemoptysis, or fungal detection. Radical surgical interventions were rare (7/35).
    • Post-operative complications, including mycotic outbursts, were serious. Of 35 patients, 13 died late from cardiorespiratory insufficiency, and only 13 of 21 survivors were considered cured.

    Conclusions:

    • Pleural aspergillosis, though infrequent, presents diverse clinical scenarios, frequently linked to prior thoracic procedures.
    • Management requires tailored therapeutic approaches, often involving less radical surgical options or medical treatment.
    • Outcomes are often guarded, with significant morbidity and mortality, highlighting the need for vigilant monitoring and management.

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