The physiologic consequences of vas ligation

Although the number of studies involving vasectomized men has been limited there appears to be no significant long-term effects. Endocrine function continues virtually unaltered. With a small number of exceptions spermatogenesis in man, as judged by a return of normal seminiferous tubule morphology, remains unchanged. However, the quality of the sperm may vary. The immunologic consequences of vasectomy have not been investigated fully. Although it is attractive to postulate that cross-reactive antibodies may develop to sperm antigens no autoimmune diseases in man secondary to vasectomy have been demonstrated. The increased incidence of atherosclerosias not been established in man. Presently, vasectomy remains a simple and safe means of permanent contraception.