Allergic granulomatosis and angiitis (Churg-Strauss)

An autopsy case of allergic granulomatosis and angiitis of Churg and Strauss is presented. The patient with a history of bronchial asthma of 3 years duration, a mild fever and hypereosinophilia, died in status asthmaticus. Cortocosteroid therapy was not given. The autopsy revealed severe eosinophilic pneumonia, disseminated necrotizing vasculitis of small arteries and veins in various stages, and extravascular granulomatous nodules. The involved organs were the lungs, liver and gastrointestinal tract, but the heart and kidneys were free from these lesions. The differences from the reported cases were discussed.