Acute exposure of rhesus monkeys to DDT: effect on carbohydrate metabolism

The administration of a single oral dose of DDT (150 mg/kg body wt.) to rhesus monkey elevated the hepatic glycogen and glycogen synthase activity but depressed the glycogen phosphorylase activity. A decrease in adenylate cyclase, both basal as well as fluoride and norepinephrine stimulated activity, was observed in liver of DDT-treated animals as compared to controls. Gluconeogenic enzymes did not record any significant change in the liver.