Diabetes mellitus in a pig-tailed macaque (Macaca nemestrina)

An eight-year-old male pig-tailed macaque developed clinical signs of diabetes mellitus: constant glucosuria, uriposia, fasting hyperglycemia, hypertriglyceridemia, marked pre-beta-hyperlipoproteinemia, glucose intolerance, hypoinsulinemia and hyperglucagonemia during intravenous glucose tolerance tests (IVGTT). During a ten-month period of intensive surveillance, the monkey's body weight decreased, but ketonemia or ketonuria were never observed. Exocrine pancreatic functions remained normal.