Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Effective pulmonary ventilation with small-volume oscillations at high frequency.

A S Slutsky, F M Drazen, R H Ingram

    Science (New York, N.Y.)
    |August 1, 1980
    PubMed
    Summary

    High-frequency oscillatory ventilation (HFOV) can achieve effective alveolar ventilation even with small tidal volumes. The key factor for efficient gas exchange is the amplitude of airflow, not frequency or stroke volume.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Quantitative composition determination by ADF-STEM at a low-angular regime: a combination of EFSTEM and 4DSTEM.

    Ultramicroscopy·2022
    Same author

    Experiments of a monolithic radial transmission line.

    The Review of scientific instruments·2016
    Same author

    Latrophilin receptors: novel bronchodilator targets in asthma.

    Thorax·2016
    Same author

    Setting mechanical ventilation in ARDS patients during VV-ECMO: where are we?

    Minerva anestesiologica·2014
    Same author

    Factors of tidal volume variation during augmented spontaneous ventilation in patients on extracorporeal carbon dioxide removal. A multivariate analysis.

    Minerva anestesiologica·2014
    Same author

    Increasing the number of lungs available for transplantation.

    Minerva anestesiologica·2013

    Area of Science:

    • Physiology
    • Respiratory Mechanics
    • Gas Exchange

    Background:

    • Alveolar ventilation is crucial for gas exchange.
    • Traditional ventilation uses tidal volumes larger than dead space.
    • High-frequency ventilation presents unique physiological challenges.

    Purpose of the Study:

    • To explain effective alveolar ventilation at high oscillation frequencies.
    • To investigate the mechanisms of gas transport during high-frequency oscillatory ventilation (HFOV).
    • To identify the primary determinant of gas exchange efficiency in HFOV.

    Main Methods:

    • Theoretical modeling of gas transport.
    • Experimental data collection during HFOV.
    • Analysis of airflow dynamics, including diffusion and convection.

    Related Experiment Videos

    Main Results:

    • Effective alveolar ventilation achieved with tidal volumes smaller than dead space at 4-30 Hz.
    • Gas exchange effectiveness is explained by combined diffusion and convection effects.
    • Oscillatory flow rate amplitude is the critical variable for gas exchange.

    Conclusions:

    • HFOV can achieve adequate ventilation with reduced tidal volumes.
    • Gas exchange efficiency in HFOV is primarily dependent on airflow amplitude.
    • Understanding these mechanisms can optimize mechanical ventilation strategies.