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[Broncholytic effectiveness of nitroglycerin].

P Gregori

    Zeitschrift Fur Die Gesamte Innere Medizin Und Ihre Grenzgebiete
    |February 1, 1980
    PubMed
    Summary
    This summary is machine-generated.

    Nitroglycerin demonstrates an acute bronchospasmolytic effect in patients with chronic obstructive bronchopneumopathies. Its bronchodilating impact, measured by FEV1 and FVK, is comparable to other bronchodilators.

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    Area of Science:

    • Pulmonology
    • Pharmacology

    Background:

    • Chronic obstructive bronchopneumopathies (COPD) involve significant bronchial obstruction.
    • Effective bronchodilator therapy is crucial for managing COPD symptoms.

    Purpose of the Study:

    • To clinically and experimentally evaluate the acute bronchospasmolytic effect of nitroglycerin.
    • To compare the efficacy of nitroglycerin with other bronchodilator agents.

    Main Methods:

    • Ninety-two patients with COPD participated in the study.
    • Nitroglycerin (0.4 mg perlingually) was administered, and ventilation parameters (FEV1, FVK) were measured.
    • Comparison with other bronchodilators including isoprenaline, adrenalin, alupent, ephedrine, euphyllin, methyl ephedrine, prednisolone, and papaverin.

    Main Results:

    Related Experiment Videos

    • Nitroglycerin showed a significant acute bronchospasmolytic effect, with a duration longer than its cardiocirculatory effects.
    • The bronchodilating effect of 0.4 mg nitroglycerin was comparable to 0.6 mg inhaled isoprenaline.
    • Nitroglycerin's efficacy ranked between euphyllin and methyl ephedrine, and its positive test frequency was similar to prednisolone and methyl ephedrine.

    Conclusions:

    • Nitroglycerin possesses a clinically relevant acute bronchodilating effect in COPD patients.
    • Nitroglycerin offers a viable therapeutic option for managing acute bronchospasm in COPD.
    • Further research may explore optimal dosing and long-term effects.