Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Biliary excretion disorders in infants: evaluation using 99mTc PIPIDA.

J H Miller, F R Sinatra, D W Thomas

    AJR. American Journal of Roentgenology
    |July 1, 1980
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Evidence for the Collective Nature of Radial Flow in Pb+Pb Collisions with the ATLAS Detector.

    Physical review letters·2026
    Same author

    Evidence for the Dimuon Decay of the Higgs Boson in pp Collisions with the ATLAS Detector.

    Physical review letters·2025
    Same author

    Evidence for Longitudinally Polarized W Bosons in the Electroweak Production of Same-Sign W Boson Pairs in Association with Two Jets in pp Collisions at sqrt[s]=13  TeV with the ATLAS Detector.

    Physical review letters·2025
    Same author

    Observation of tt[over ¯] Production in Pb+Pb Collisions at sqrt[s_{NN}]=5.02  TeV with the ATLAS Detector.

    Physical review letters·2025
    Same author

    Search for Dark Matter Produced in Association with a Dark Higgs Boson in the bb[over ¯] Final State Using pp Collisions at sqrt[s]=13  TeV with the ATLAS Detector.

    Physical review letters·2025
    Same author

    Search for Magnetic Monopole Pair Production in Ultraperipheral Pb+Pb Collisions at sqrt[s_{NN}]=5.36  TeV with the ATLAS Detector at the LHC.

    Physical review letters·2025

    New hepatobiliary imaging agents, N-substituted iminodiacetic acids, offer improved evaluation of infant biliary excretion disorders. Technetium-99m labeled PIPIDA provides better imaging and reduced radiation compared to older agents.

    Area of Science:

    • Hepatobiliary imaging
    • Nuclear medicine
    • Pediatric diagnostics

    Background:

    • N-substituted iminodiacetic acids represent a novel class of hepatobiliary imaging agents.
    • These agents are rapidly extracted by hepatocytes and excreted into the biliary tree following intravenous administration.

    Purpose of the Study:

    • To evaluate the utility of 99mTc-labeled p-isopropylacetanilido-iminodiacetic acid (PIPIDA) in diagnosing biliary excretion disorders in infants.
    • To compare the efficacy and safety of 99mTc PIPIDA with the previously used agent, 131I rose bengal.

    Main Methods:

    • Intravenous administration of 99mTc PIPIDA.
    • Gamma-camera imaging for assessing hepatobiliary function.
    • Evaluation of infants with neonatal hepatitis, intrahepatic cholestatic jaundice, and biliary atresia.

    Related Experiment Videos

  • Follow-up imaging of surgically created portoenterostomies.

    • Main Results:

    • 99mTc PIPIDA demonstrated rapid hepatobiliary uptake and excretion.
    • The agent facilitated excellent gamma-camera imaging, providing improved diagnostic statistics.
    • Significant reduction in radiation dose to the liver compared to 131I rose bengal.

    Conclusions:

    • 99mTc PIPIDA is a valuable and desirable agent for evaluating biliary excretion disorders in infants.
    • Its improved imaging quality and reduced radiation profile make it superior to older agents like 131I rose bengal.