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Microfiltration of stored blood.

E D Loong

    Anaesthesia and Intensive Care
    |May 1, 1980
    PubMed
    Summary

    Microaggregates in stored blood can cause lung issues. Using 20 micrometer filters effectively removes these particles, preventing adverse effects during blood transfusions.

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    Area of Science:

    • Transfusion Medicine
    • Hematology
    • Pulmonary Physiology

    Background:

    • Stored blood develops microaggregates, composed of cellular debris and protein aggregates.
    • These microaggregates can potentially cause pulmonary complications during transfusion.
    • Previous evidence on the clinical significance of microaggregates was limited and contradictory.

    Purpose of the Study:

    • To investigate the impact of microaggregates on pulmonary function during blood transfusion.
    • To evaluate the efficacy of different microaggregate filtration methods.

    Main Methods:

    • Assessed pulmonary arteriovenous shunting and alveolar-arterial oxygen differences in patients receiving transfusions.
    • Compared standard 170 micrometer filtration with 20 micrometer Dacron wool filtration.
    • Examined alternative methods for microaggregate reduction, including fresh blood, frozen-thawed blood, and washed red cells.

    Main Results:

    • Transfusion through standard 170 micrometer filters significantly increased pulmonary shunting and oxygen differences.
    • These adverse pulmonary changes were not observed when using 20 micrometer filters.
    • Current alternative methods for microaggregate reduction are not routinely feasible.

    Conclusions:

    • Microfiltration of stored blood is crucial to prevent transfusion-related pulmonary complications.
    • 20 micrometer Dacron wool filters are effective in removing harmful microaggregates.
    • Routine filtration of all transfused stored blood is recommended, with 40 micrometer screen filters offering practical advantages.

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