[Adenylate cyclase activity in capillary walls and in hairy cells during experimental carcinogenesis]

Adenylate cyclase activity in "hairy" cells and blood capillary wall in the region of implanting the carcinogen DMBA pill into the rat brain was studied by electron microscopy 1--7 days following the implantation. The enzymatic activity of the apical plasmalemma of the "hairy" cells as well as that in the basal layer and on the basal surface of the endothelial cells of the blood capillary wall facing the carcinogen pill was shown to increase with time. The evidence obtained confirms the suggestion that DMBA stimultes cell membrane adenylate cyclase and that the latter favours the enhancement of the synthesis of cyclic adenosine monophosphate which plays an important role in the intensification of cell metabolism.