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Standardized laboratory animals their need. Why the nonhuman primate?

S S Kalter

    Developments in Biological Standardization
    |January 1, 1980
    PubMed
    Summary

    The need for laboratory animals, especially nonhuman primates, will persist. International standardization guidelines and breeding programs are crucial for ensuring reliable research outcomes.

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    Area of Science:

    • Veterinary science
    • Primatology
    • Biomedical research

    Background:

    • Laboratory animal use is increasing, necessitating standardized species.
    • Nonhuman primates are vital research models due to their phylogenetic closeness to humans.
    • Currently, nonhuman primates often lack standardization, originating directly from natural environments.

    Purpose of the Study:

    • To highlight the need for international guidelines for standardizing nonhuman primates in research.
    • To propose the development of breeding programs for key primate species.
    • To advocate for standardized information crucial for simian research.

    Main Methods:

    • Review of current practices in laboratory animal standardization.
    • Analysis of the unique challenges in standardizing nonhuman primates.
    • Proposal for international collaboration and leadership.

    Main Results:

    • Existing laboratory animals are largely standardized, unlike nonhuman primates.
    • Increasing use of nonhuman primates in research underscores the need for standardization.
    • A clear gap exists in standardized conditioning and information for nonhuman primates.

    Conclusions:

    • International cooperation is essential for establishing global standards for nonhuman primates.
    • The World Health Organization (WHO) is suggested to lead efforts in breeding programs and standardization.
    • Standardized nonhuman primates will enhance the reliability and reproducibility of biomedical research.

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