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Ascorbic acid requirements of the trained monkey as determined by blood ascorbate levels
Summary
Young monkeys require double the vitamin C (ascorbate) of mature monkeys to prevent scurvy. Dietary incorporation of ascorbate is more efficient than supplements for maintaining adequate blood levels.
Area of Science:
- Primate nutrition
- Biochemistry
Background:
- Ascorbate (vitamin C) is essential for preventing scurvy.
- Environmental stress can increase ascorbate requirements.
- Establishing optimal dietary intake is crucial for primate health.
Purpose of the Study:
- To determine the daily ascorbate requirements for mature and young monkeys.
- To compare the efficacy of dietary ascorbate versus oral supplements.
- To assess the relationship between blood and tissue ascorbate levels.
Main Methods:
- Four trained monkeys were used, conditioned to minimize stress.
- Ascorbate requirements were assessed by comparing blood levels to known supplement doses.
- Plasma, whole blood, and leucocyte ascorbate levels were measured.
Main Results:
- Mature monkeys required 3 mg/kg/day, while young monkeys required 6 mg/kg/day of ascorbate.
- Dietary ascorbate was more effective than oral supplements in maintaining blood levels.
- Leucocyte ascorbate levels indicated potentially minimal tissue concentrations despite acceptable blood levels.
Conclusions:
- Younger, immature monkeys have higher ascorbate needs than mature monkeys.
- Dietary integration of ascorbate is more efficient for maintaining physiological levels.
- Further research may be needed to ensure adequate tissue saturation.