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Insulin resistance: definition and treatment
American Journal of Hospital Pharmacy
|August 1, 1980
Summary
This review details insulin resistance, covering immune and nonimmune types. Treatment options range from lifestyle changes and specific insulins to newer recombinant DNA human insulin therapies.
Area of Science:
- Endocrinology
- Immunology
Background:
- Insulin resistance is a condition where the body's cells do not respond effectively to insulin.
- It can be broadly classified into immune and nonimmune types, each with distinct causes and management strategies.
Observation:
- Immune insulin resistance involves antibodies against exogenous insulin or insulin receptors.
- Nonimmune insulin resistance is linked to conditions like obesity, ketoacidosis, infections, and endocrinopathies.
Findings:
- Treatment strategies include diet, weight management, high-dose insulin, less antigenic insulin variants (pork, fish, sulfated), oral hypoglycemics (tolbutamide), and immunosuppressants (corticosteroids).
- Recombinant DNA technology for human insulin production offers a promising alternative for patients with high antibody levels against animal-sourced insulins.
Implications:
- Accurate diagnosis of true insulin resistance is crucial before initiating aggressive treatment.
- Advancements in insulin production and understanding of resistance mechanisms improve patient care and therapeutic outcomes.
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