[Effect of thiophosphamide on the frequency of chromosome aberrations in cells heterozygous for...

Chromosome aberration rate in ataxia-teleangiectasia (AT) heterozygotes exposed to thiophosphamide in lymphocyte culture was compared to that in control donors. AT heterozygotes demonstrated an increased number of chromosome aberrations. The patterns of concentraion relationships in AT heterozygotes are depictable by the same equation as in control donors. However, the expected chromosome aberration rate in AT heterozygotes proved to be elevated, indicating the increased sensitivity of AT heterozygotes to the exposure to low doses of thiophosphamide, since no experimental differences were found in the spontaneous chromosome aberration rate between AT heterozygotes and control donors.