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Related Experiment Videos

Choroid plexus blood flow in the sheep.

R B Page, D J Funsch, R W Brennan

    Brain Research
    |September 22, 1980
    PubMed
    Summary

    This study measured choroid plexus blood flow in sheep, finding it differs from cerebral cortex blood flow, particularly during hypercarbia and hypertension. These findings suggest unique regulatory mechanisms in the choroid plexus.

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    Area of Science:

    • Physiology
    • Cerebrovascular Research
    • Neuroscience

    Background:

    • The choroid plexus is crucial for cerebrospinal fluid production and maintaining brain homeostasis.
    • Understanding choroid plexus blood flow regulation is vital for comprehending its function and potential role in neurological disorders.

    Purpose of the Study:

    • To quantify basal choroid plexus blood flow in adult female sheep.
    • To investigate the autoregulation of choroid plexus blood flow in response to changes in arterial carbon dioxide tension and mean arterial blood pressure.
    • To compare choroid plexus blood flow dynamics with cerebral cortical blood flow in the same animals.

    Main Methods:

    • Utilized the radioactive microsphere technique for precise blood flow measurement.
    • Determined basal blood flow rates.
    • Assessed responses to induced hypocarbia and hypercarbia.
    • Evaluated the impact of pharmacogenically induced hypertension.

    Main Results:

    • Mean basal choroid plexus blood flow was 601 ml/100 g/min.
    • Hypocarbia caused a 31% reduction in choroid plexus blood flow, similar to cortical changes.
    • Hypercarbia resulted in a modest 27% increase in choroid plexus blood flow, contrasting sharply with a 199% increase in cortical blood flow.
    • Pharmacogenic hypertension led to a significant decrease in choroid plexus blood flow, unlike cerebral cortex blood flow.

    Conclusions:

    • Choroid plexus blood flow exhibits distinct autoregulatory patterns compared to cerebral cortical blood flow.
    • The limited response to hypercarbia and the decrease during hypertension suggest unique vascular properties, potentially due to the absence of a blood-brain barrier.
    • These findings highlight the specialized physiology of the choroid plexus vasculature.

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