HLA-D antigens in a Czech population and their association with HLA-DR antigens

HLA-D specificities Dwl through 11 and HLA-DR antigens DRwl through WIA8 were studied on a panel of 101 unrelated individuals of the Prague HLA panel. THe HLA-D specificities were defined by means of the HLA-D homozygous typing cells in MLC test, the HLA-DR specificities were tested on B cells using VIIth Histocompatibility Workshop antisera. In the panel tested, the antigen and gene frequencies of eleven HLA-D determinants, the associations between the HLA-B and HLA-D antigens as well as between the HLA-D and HLA-DR antigens were determined. Significant associations between some of the HLA-D and HLA-DR antigens were found.