Related Experiment Video
Updated: Aug 4, 2026

A Novel Approach for the Administration of Medications and Fluids in Emergency Scenarios and Settings
Published on: November 9, 2016
Pharmacokinetic evaluation of a new maintenance solution for severely injured patients
Abstract:
Nine severely injured patients (SIP) and 9 healthy controls received 20 min iv infusions of Aminoplasmal-LS-10 (2.15 ml/kg body wt containing 0.215 g amino acids). Employing the values of the plasma amino acid (AA) concentrations 3, 7, 15, 30, 45, 70, and 150 min after the end of the infusion, we calculated the elimination half-life (t 1/2), the elimination constant (k2), the total clearance (Cltot), and the transfer of the individual AA. The AA showed t 1/2 between 6 (Glu) and 23 (Thr) min. Comparing the metabolic kinetics of healthy controls and SIP, there were no statistical differences in t 1/2 or in k2. In the SIP, nearly all plasma AA showed increased transfer and Cltot, significantly for Thr (p < 0.05), Pro, Gly, Ala, Arg (p < 0.02), Glu (p < 0.01), and Met (p < 0.005). In contrast, the Cltot for Phe and Tyr were decreased. Except for Phe, Tyr, Met (enhanced values) and Arg (no change), the fasting values of AA concentrations in the SIP were diminished compared to those in the healthy controls. Based on the measured transfer, we have developed a new maintenance solution adapted to SIP. Compared with Aminoplasmal, it is necessary to apply AA concentrations which are increased in Lys, His, Phe, Tyr, Val, Ala, and Ser, and reduced in Arg, Pro, Leu, Ile, and Gly.
More Related Videos
04:53A Clinical Trial Assessing the Safety, Efficacy, and Delivery of Olive-Oil-Based Three-Chamber Bags for Parenteral Nutrition
Published on: September 20, 2019
11:17Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses
Published on: August 30, 2018
Related Concept Videos
Rational Dosage Regimen: Maintenance Dose and Loading Dose
In most cases, drugs are administered repetitively or infused continuously to maintain a steady-state concentration in the body. At a steady state,...
Dosage Regimens: Partial Pharmacokinetic Parameters
Determination of Multiple Dosing Parameters: Steady-State, Minimum and Maximum Concentrations
Determination of Multiple Dosing Parameters: Loading and Maintenance Doses
Pharmacokinetics in Pediatric Patients: Drug Excretion
Drug Dosing in Renal Diseases: Dose Adjustments Based on Drug Clearance and Elimination Rate Constant