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Hemoglobin I (alpha 16 lys leads to glu) was identified in association with hemoglobins C and A in a black American woman who had no clinical or hematologic disease. Her erythrocytes contained four major hemoglobins, all of which were separable by DEAE-cellulose column chromatography. Nearly 50% of the total recovered alpha I-chains were present in combination with beta C, suggesting that there may have been preferential formation of the alpha I beta C hybrid hemoglobin.
Hemoglobin I (alpha 16 lys leads to glu) was identified in association with hemoglobins C and A in a black American woman who had no clinical or hematologic disease. Her erythrocytes contained four major hemoglobins, all of which were separable by DEAE-cellulose column chromatography. Nearly 50% of the total recovered alpha I-chains were present in combination with beta C, suggesting that there may have been preferential formation of the alpha I beta C hybrid hemoglobin.