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Platelet adsorption-source of error in reference controls.

W L Ryan, G L Curtis, H Sornson

The American Journal of Medical Technology

|September 1, 1980

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Chemical cross-linking strengthens platelet membranes for reference controls, but causes surface adsorption. Adsorption is inhibited by surfactants or eliminated by polyethylene glycol without affecting conductivity.

Area of Science:

Biotechnology
Materials Science

Background:

Platelet reference controls are crucial for accurate blood testing.
Chemical cross-linking, typically with glutaraldehyde, is used to strengthen platelet membranes.

Purpose of the Study:

To investigate the surface adsorption properties of chemically cross-linked platelets.
To evaluate methods for mitigating unwanted adsorption in platelet reference controls.

Main Methods:

Preparation of platelet reference controls using glutaraldehyde cross-linking.
Testing commercially available reference controls for surface adsorption.
Evaluating the effects of surfactants and polyethylene glycol on platelet adsorption.

Main Results:

Related Experiment Videos

Glutaraldehyde cross-linking results in strong adsorption of platelets to plastic and glass surfaces.

Surfactants reduce adsorption but cause a decrease in apparent platelet size.

Polyethylene glycol effectively eliminates adsorption without altering sample conductivity.

Conclusions:

Surface adsorption is a significant issue with current platelet reference controls.
Polyethylene glycol presents a promising solution for improving platelet reference control stability and reliability.