Carbodiimide-dependent inactivation of dihydrofolate reductase

Human thymidylate synthase is in the closed conformation when complexed with dUMP and raltitrexed, an antifolate drug.

Biochemistry·2001

Structure of human thymidylate synthase suggests advantages of chemotherapy with noncompetitive inhibitors.

The Journal of biological chemistry·2001

Cation binding and thermostability of FTHFS monovalent cation binding sites and thermostability of N10-formyltetrahydrofolate synthetase from Moorella thermoacetica.

Biochemistry·2000

Catalytic cysteine of thymidylate synthase is activated upon substrate binding.

Biochemistry·2000

The crystal structure of N(10)-formyltetrahydrofolate synthetase from Moorella thermoacetica.

Biochemistry·2000

Kinetic studies on drug-resistant variants of Escherichia coli thymidylate synthase: functional effects of amino acid substitutions at residue 4.

Archives of biochemistry and biophysics·1999

Anti-neuroinflammatory and neuroprotective effects of sweroside and swertiamarin from Swertia bimaculata in an in vitro microglial activation model.

Biochemical and biophysical research communications·2026

TARM1 may contribute to acute respiratory distress syndrome progression via regulating M1 macrophage polarization.

Biochemical and biophysical research communications·2026

Exosomal innovations in neurodegenerative disorders: Emerging insights and intranasal route.

Biochemical and biophysical research communications·2026

Impact of glycolipid particles in fetal bovine serum on the flow cytometric detection of cell-surface SSEA-4.

Biochemical and biophysical research communications·2026

Non-coding RNAs in diabetic cardiomyopathy: Mechanistic insights, diagnostic and prognostic potential, and therapeutic perspectives.

Biochemical and biophysical research communications·2026

Arl8b and its role in the development of systemic lupus erythematosus by regulating T-cell number.

Biochemical and biophysical research communications·2026

Cube-root organization of electrolyte activity coefficients: experimental trends and an electrostatic framework.

Physical chemistry chemical physics : PCCP·2026

Temperature-Driven Shift in the Role of Dissolved Black Carbon in Ferrihydrite-Phosphorus Interactions: From Inhibition to Promotion.

Journal of agricultural and food chemistry·2026

Quantum state-to-state reaction dynamics of F + HD → HF + D via a single partial wave shape resonance state.

Nature communications·2026

Early dobutamine response to delayed cerebral ischemia affected by vasospasm after subarachnoid hemorrhage: Serial cerebral blood flow analyses using O-15-water positron-emission tomography - A report of two cases.

Brain circulation·2026

Single-molecule thermodynamics of rotary molecular motors in oxidative phosphorylation: Application to physical transport processes.

Bio Systems·2026

Evaluation of Vancomycin Bolus/Standard and Continuous Infusion on Nephrotoxicity in a Rat Model.

International journal of antimicrobial agents·2026

Related Experiment Videos

Carbodiimide-dependent inactivation of dihydrofolate reductase

Related Concept Videos

Human thymidylate synthase is in the closed conformation when complexed with dUMP and raltitrexed, an antifolate drug.

Structure of human thymidylate synthase suggests advantages of chemotherapy with noncompetitive inhibitors.

Cation binding and thermostability of FTHFS monovalent cation binding sites and thermostability of N10-formyltetrahydrofolate synthetase from Moorella thermoacetica.

Catalytic cysteine of thymidylate synthase is activated upon substrate binding.

The crystal structure of N(10)-formyltetrahydrofolate synthetase from Moorella thermoacetica.

Kinetic studies on drug-resistant variants of Escherichia coli thymidylate synthase: functional effects of amino acid substitutions at residue 4.

Anti-neuroinflammatory and neuroprotective effects of sweroside and swertiamarin from Swertia bimaculata in an in vitro microglial activation model.

TARM1 may contribute to acute respiratory distress syndrome progression via regulating M1 macrophage polarization.

Exosomal innovations in neurodegenerative disorders: Emerging insights and intranasal route.

Impact of glycolipid particles in fetal bovine serum on the flow cytometric detection of cell-surface SSEA-4.

Non-coding RNAs in diabetic cardiomyopathy: Mechanistic insights, diagnostic and prognostic potential, and therapeutic perspectives.

Arl8b and its role in the development of systemic lupus erythematosus by regulating T-cell number.

Cube-root organization of electrolyte activity coefficients: experimental trends and an electrostatic framework.

Temperature-Driven Shift in the Role of Dissolved Black Carbon in Ferrihydrite-Phosphorus Interactions: From Inhibition to Promotion.

Quantum state-to-state reaction dynamics of F + HD → HF + D via a single partial wave shape resonance state.

Early dobutamine response to delayed cerebral ischemia affected by vasospasm after subarachnoid hemorrhage: Serial cerebral blood flow analyses using O-15-water positron-emission tomography - A report of two cases.

Single-molecule thermodynamics of rotary molecular motors in oxidative phosphorylation: Application to physical transport processes.

Evaluation of Vancomycin Bolus/Standard and Continuous Infusion on Nephrotoxicity in a Rat Model.

Related Experiment Videos

Carbodiimide-dependent inactivation of dihydrofolate reductase

Related Concept Videos

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