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Related Experiment Videos

Biochemical changes associated with severe trauma.

A Shenkin, M Neuhäuser, J Bergström

    The American Journal of Clinical Nutrition
    |October 1, 1980
    PubMed
    Summary

    Providing amino acids with energy substrates significantly improves nitrogen balance in trauma patients. However, most biochemical markers did not reflect these nutritional changes.

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    Area of Science:

    • Biochemistry
    • Nutrition
    • Trauma Care

    Background:

    • Severe trauma significantly impacts nutritional status.
    • Intravenous nutritional support is critical for post-trauma recovery.
    • Understanding the effects of different nutritional regimens is essential.

    Purpose of the Study:

    • To evaluate the impact of varying intravenous nutritional regimens on biochemical indices of nutritional status.
    • To determine the effect of high nitrogen (N) intake on nitrogen balance post-trauma.
    • To assess muscle protein breakdown and its relation to nutritional support.

    Main Methods:

    • Studied two groups of patients for 8 days post-severe trauma.
    • Administered isocaloric intravenous regimens with and without high amounts of amino acids (high N).

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  • Measured biochemical indices including serum proteins, acute phase reactants, and amino acid levels. Measured 3-methylhistidine excretion.

    • Main Results:

    • High N regimen significantly improved nitrogen balance compared to the regimen without amino acids.
    • Serum albumin, transferrin, prealbumin, and retinol-binding protein decreased in both groups.
    • Muscle protein breakdown, indicated by 3-methylhistidine excretion, was increased and similar in both groups, unaffected by amino acid provision.

    Conclusions:

    • Intravenous amino acid provision, along with energy substrates, significantly enhances nitrogen balance in the immediate post-trauma period.
    • Most measured biochemical variables, except for plasma essential amino acids, did not reflect the improved nitrogen balance.
    • Muscle protein breakdown post-trauma appears independent of immediate amino acid nutritional support.