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Related Experiment Videos

Hyperfunctioning thyroid nodules in children.

K Abe, M Konno, T Sato

    American Journal of Diseases of Children (1960)
    |October 1, 1980
    PubMed
    Summary
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    This study reports on two pediatric cases of hyperfunctioning thyroid nodules, a rare condition. Surgical removal confirmed adenomatous goiter as the cause in both young patients.

    Area of Science:

    • Pediatric Endocrinology
    • Thyroidology
    • Surgical Pathology

    Background:

    • Hyperfunctioning thyroid nodules are uncommon in children.
    • This study investigates two pediatric cases presenting with thyroid masses.

    Observation:

    • Two girls, aged 9 and 11, presented with palpable thyroid nodules.
    • Scintiscans revealed hyperfunctioning nodules in both patients.
    • Biochemical tests showed distinct hormonal profiles, with one exhibiting hyperthyroidism and suppressed TSH response to TRH, while the other had normal thyroid function tests.

    Findings:

    • Surgical excision of the nodules was performed in both cases.
    • Microscopic examination confirmed adenomatous goiter.
    • Post-operative scintiscans demonstrated radioactivity in the contralateral lobe and ectopic thyroid tissue, respectively.

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    Implications:

    • Highlights the importance of considering hyperfunctioning thyroid nodules in pediatric patients with thyroid masses.
    • Demonstrates the utility of scintigraphy and hormonal assays in diagnosis.
    • Emphasizes adenomatous goiter as a potential cause in this age group.