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Establishing full-term human pregnancies using cleaving embryos grown in vitro
British Journal of Obstetrics and Gynaecology
|September 1, 1980
Summary
This study demonstrates successful human pregnancies using in vitro fertilization (IVF) and embryo transfer. Optimal pregnancy outcomes were observed when embryos were transferred in the late evening, suggesting a diurnal rhythm influences implantation.
Area of Science:
- Reproductive Medicine
- Human Embryology
- In Vitro Fertilization
Background:
- Assisted reproductive technologies aim to establish successful pregnancies.
- Understanding the optimal timing for embryo transfer is crucial for IVF success.
Purpose of the Study:
- To describe the establishment of human pregnancies using in vitro fertilization and embryo transfer.
- To investigate the role of diurnal rhythms in embryo implantation and pregnancy establishment.
Main Methods:
- Oocyte aspiration via laparoscopy during the natural menstrual cycle, timed by luteinizing hormone (LH) surge detection.
- Follicular growth assessment using estrogen measurements.
- In vitro fertilization, embryo culture, and transcervical embryo transfer.
- Monitoring of pregnancy establishment and outcomes.
Main Results:
- Successful fertilization and cleavage were achieved in 34 instances.
- Thirty-two embryos were transferred to patients.
- Four pregnancies were established.
- All four pregnancies occurred when embryos were transferred in the late evening.
- Oocytes used for successful pregnancies were retrieved 24 hours or longer after the LH surge began.
Conclusions:
- The timing of embryo transfer, particularly in the late evening, may play a significant role in successful human pregnancy establishment via IVF.
- A diurnal rhythm appears to influence the success of embryo implantation.
- Further research into the circadian aspects of reproductive processes is warranted.