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Related Experiment Videos

J segment in human delta chains.

C P Milstein, E V Deverson

    Immunology
    |August 1, 1980
    PubMed
    Summary
    This summary is machine-generated.

    Researchers sequenced a human delta chain fragment, revealing the peptide linking variable and constant regions. This finding suggests a potential short joining (J) gene segment in human heavy chains.

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    Area of Science:

    • Immunogenetics
    • Molecular Biology
    • Human Genetics

    Background:

    • The human delta (δ) chain is a component of certain T cell receptors.
    • Understanding the structure of immunoglobulin heavy chains is crucial for immunology.
    • Previous research has characterized various human heavy chain classes and subclasses.

    Purpose of the Study:

    • To determine the complete amino acid sequence of a specific cyanogen bromide fragment (ErI) of the human delta chain.
    • To identify the peptide segment responsible for joining the variable (V) and constant (Cδ1) regions of the delta chain.
    • To compare this sequence with homologous regions in other human heavy chain isotypes.

    Main Methods:

    • Cyanogen bromide fragmentation of the human delta chain.

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  • Amino acid sequencing of the resulting fragment (ErI).
  • Comparative sequence analysis with other human heavy chain regions.

    • Main Results:

    • The complete sequence of the ErI fragment of the human delta chain was determined.
    • This fragment contains the critical peptide linking the Vδ and Cδ1 regions.
    • Sequence comparison revealed similarities and differences with homologous regions of other human heavy chain classes.

    Conclusions:

    • The identified peptide sequence provides insights into the structural organization of the human delta chain.
    • The findings support the hypothesis that human delta chains, like other heavy chains, may possess a short joining (J) gene segment in their chromosomal DNA.
    • Further investigation into the genetic basis of human heavy chain diversity is warranted.