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Hyperalimentation in primates. A nutritional model.

C L Hobbs, J L Mullen, M H Gertner

    JPEN. Journal of Parenteral and Enteral Nutrition
    |September 1, 1980
    PubMed
    Summary
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    Macaque monkeys are suitable for parenteral nutrition research. This study found few complications and good health maintenance in monkeys undergoing long-term intravenous nutrition, supporting their use as a model.

    Area of Science:

    • Veterinary Medicine
    • Nutritional Science
    • Primate Research

    Background:

    • Parenteral nutrition (PN) research requires suitable animal models.
    • Subhuman primates offer physiological similarities to humans, but their utility in PN studies needs validation.

    Purpose of the Study:

    • To evaluate the suitability of macaques as a laboratory animal model for parenteral nutrition research.
    • To assess the feasibility and safety of long-term intravenous nutrition in chronically chair-restrained macaques.

    Main Methods:

    • 18 male macaques were adapted to chronic chair restraint.
    • Animals received intravenous nutrition via inferior vena cava catheters for 1- and 2-week periods.
    • Catheter dwell times and animal health parameters were monitored.

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    Main Results:

    • Animals tolerated chronic restraint and catheterization well, with low morbidity.
    • Catheter and metabolic complications during PN infusion were minimal.
    • Macaques maintained stable weight, serum albumin, transferrin levels, and positive nitrogen balance.

    Conclusions:

    • Macaques are a highly suitable model for parenteral nutrition research.
    • The controlled environment and long-term study capabilities make macaques valuable for nutritional studies.
    • This model supports further investigation into PN in primate subjects.