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Amphetamine and maternal behavior: dose response relationships.

M Piccirillo, J E Alpert, D J Cohen

    Psychopharmacology
    |January 1, 1980
    PubMed
    Summary
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    d-amphetamine disrupts maternal care in rats even at low doses. This disruption affects various behaviors, including nursing, and is more pronounced in younger offspring, indicating a dose-dependent impairment.

    Area of Science:

    • Neuroscience
    • Behavioral Science
    • Pharmacology

    Background:

    • Maternal behavior is crucial for offspring survival and development.
    • Amphetamines are known psychostimulants with potential effects on behavior.

    Purpose of the Study:

    • To investigate the effects of d-amphetamine on maternal behavior in primiparous rats.
    • To determine dose-dependent and age-dependent impacts of d-amphetamine on maternal care.

    Main Methods:

    • Primiparous rats were administered varying doses of d-amphetamine (0.05-1.50 mg/kg) at specific offspring developmental stages (3-4 and 10-11 days).
    • Maternal behavior was assessed using a multidimensional analysis, evaluating parameters like intercontact interval, retrieval latency, nursing time, and nest building.

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    Main Results:

    • D-amphetamine disrupted multiple aspects of maternal behavior, including nursing and retrieval, even at low doses (0.25 mg/kg).
    • The disruptive effects were dose-dependent for most behaviors, except for the number of corners for retrieval and time spent nest building.
    • Amphetamine's impact on nursing was more significant in mothers of younger pups (3-4 days) compared to older pups (10-11 days).

    Conclusions:

    • Amphetamine impairs maternal care in a dose-dependent manner, likely due to excessive arousal and locomotor stimulation.
    • The findings highlight the sensitivity of maternal behavior to psychostimulants and suggest age-related differences in drug effects on caregiving.