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Systemic lupus erythematosus and lymphoma.

D W Milligan, J G Chang

    Acta Haematologica
    |January 1, 1980
    PubMed
    Summary

    Systemic lupus erythematosus (SLE) can be associated with non-Hodgkin's lymphoma in young women. Early lymph node biopsy is recommended if lymphadenopathy develops in SLE patients.

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    Area of Science:

    • Rheumatology
    • Oncology
    • Pathology

    Background:

    • Systemic lupus erythematosus (SLE) is a chronic autoimmune disease.
    • Malignancy, including lymphoma, is a known complication of SLE.
    • The association between SLE and non-Hodgkin's lymphoma (NHL) requires further investigation.

    Observation:

    • Two cases of young women with SLE who developed non-Hodgkin's lymphoma are presented.
    • The time from SLE diagnosis to lymphoma development was 4 years and 4 months.
    • In one case, the lymphoma was primarily located in the lung.

    Findings:

    • The study highlights a potential link between SLE and NHL.
    • The latency period between SLE diagnosis and lymphoma development varied.
    • Extranodal involvement, such as pulmonary lymphoma, can occur in SLE patients.

    Implications:

    • Lymphadenopathy in patients with SLE should prompt early investigation.
    • Prompt lymph node biopsy is crucial for timely diagnosis of lymphoma in SLE.
    • This underscores the importance of vigilant monitoring for secondary malignancies in autoimmune diseases.

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