Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Coagulation inhibitors.

J J Corrigan

    The American Journal of Pediatric Hematology/Oncology
    |January 1, 1980
    PubMed
    Summary

    Autoimmune diseases can cause hypocoagulability through various coagulation inhibitors. These include circulating anticoagulants, abnormal procoagulants, and reduced factor levels, impacting blood clotting.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Neuropsychiatric Lupus with Antibody-Mediated Striatal Encephalitis.

    AJNR. American journal of neuroradiology·2018
    Same author

    TRPV1 antagonists that cause hypothermia, instead of hyperthermia, in rodents: Compounds' pharmacological profiles, in vivo targets, thermoeffectors recruited and implications for drug development.

    Acta physiologica (Oxford, England)·2018
    Same author

    Autoimmune Encephalitis: Pathophysiology and Imaging Review of an Overlooked Diagnosis.

    AJNR. American journal of neuroradiology·2017
    Same author

    Treatment of chronic haemophilic synovitis in humans with D-penicillamine.

    Haemophilia : the official journal of the World Federation of Hemophilia·2003
    Same author

    Hemolytic-uremic syndrome.

    Pediatrics in review·2001
    Same author

    Tulane University School of Medicine.

    Academic medicine : journal of the Association of American Medical Colleges·2000

    Area of Science:

    • Hematology
    • Immunology
    • Clinical Pathology

    Background:

    • Autoimmune conditions are frequently associated with dysregulation of the hemostatic system.
    • Coagulation inhibitors are a significant factor contributing to bleeding disorders in autoimmune states.
    • Understanding these inhibitors is crucial for managing associated hypocoagulability.

    Purpose of the Study:

    • To review the different types of coagulation inhibitors found in autoimmune diseases.
    • To elucidate the mechanisms by which these inhibitors cause hypocoagulability.
    • To discuss the laboratory and clinical manifestations of coagulation inhibitors in autoimmune settings.

    Main Methods:

    • Review of literature on coagulation inhibitors in autoimmune states.
    • Analysis of mechanisms leading to hypocoagulability.
    • Discussion of diagnostic laboratory findings and clinical presentations.

    Main Results:

    • Hypocoagulability arises from three primary mechanisms: circulating anticoagulants, abnormal procoagulants, or reduced coagulation factor levels.
    • Circulating anticoagulants are the most common type, acting via neutralization of specific factors or interference with factor interactions.
    • Each inhibitor type presents distinct laboratory and clinical features.

    Conclusions:

    • Coagulation inhibitors are key players in the hypocoagulability seen in autoimmune diseases.
    • The diverse mechanisms of inhibition necessitate a thorough understanding for accurate diagnosis and management.
    • Further research into specific inhibitor profiles can improve patient outcomes.

    Related Experiment Videos