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Related Experiment Videos

[Lupus erythematosus profundus: two cases with ultrastructural study].

L Schnitzler, J L Verret, B Schubert

    Annales De Dermatologie Et De Venereologie
    |February 1, 1978
    PubMed
    Summary

    Lupus erythematosus profundus, a rare lupus variant, presents as deep skin nodules. Diagnosis is challenging, but characteristic ultrastructural findings like virus-like inclusions aid identification.

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    Area of Science:

    • Dermatology
    • Pathology
    • Immunology

    Background:

    • Lupus erythematosus profundus (LEP) is an uncommon variant of lupus erythematosus.
    • It affects deeper skin layers (corium and panniculus), often causing diagnostic challenges.

    Observation:

    • Cases involve young men with facial subcutaneous nodules that lead to depressed scars.
    • Histology shows dense dermal infiltrate (lymphocytes, histiocytes) around skin appendages and in fat tissue.
    • Epidermal changes include basal cell degeneration, atrophy, and basement membrane thickening.

    Findings:

    • Direct immunofluorescence revealed IgG deposits at the dermo-epidermal junction in one case.
    • Ultrastructural analysis identified paramyxovirus-like inclusions in dermal cells and keratinocytes.

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  • Basal lamina abnormalities (folds, projections) and intracellular vacuoles/formations were noted.

    • Implications:

    • Ultrastructural findings are crucial for diagnosing isolated forms of lupus erythematosus profundus.
    • The condition appears distinct from systemic lupus erythematosus, lacking systemic signs.
    • Antimalarial drugs demonstrate efficacy in treating the characteristic nodules.