[Effect of inorganic and yeast-borne tin on rats]

Tin incorporated in baker's yeast was applied to male Wistar rats over 21 days. The doses corresponded to 1/500 or 1/50 of LD50 of SnCl2 x 2H2O and 1/50 of LD50 of SnCl2 x 2H2O. The effects on activities of certain selected enzymes as well as on tin levels in liver and kidneys were tested. Some of the enzymes tested were found to reflect even exposures much below the point recordable from accumulation of the metal. Serum lactate-dehydrogenase is recommended as a sensitive indicator enzyme in the context of tin exposure.