[Memory facilitation induced by delayed electric stimulation of the entorhinal cortex in mice]

A subconvulsive bilateral stimulation of the lateral entorhinal cortex has been applied in BALB/c mice at different time intervals after an appetitive operant conditioning task. 24 hrs later, compared to the control subjects, the performance was improved only in animals stimulated 30 min. after the first learning session. No change was observed in animals stimulated 30 sec. or 3 hrs. post-trial. These results suggest that entorhinal cortex is involved rather late in memory processes.