[Modification of crossing over frequency in female Drosophila by using certain chemical compounds]

The effect of acridine yellow, pyrimidine derivative and hydrochinone on recombination frequency in the sex chromosome of Drosophila melanogaster females was investigated. Recombination activity of the first two heterocyclic compounds was determined. Coincidence of the modification effect of exchange frequency with the definite stage of the meiotic cycle in Drosophila females on one hand, and the proposed mechanism of interacting studied preparations with DNA molecule on the other hand, are the evidence of coincidence of crossing-over induction process with DNA premeiotic synthesis stage. The data on specificity of the different sites of sex chromosome concerning exchange induction are obtained.