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Communicating hydrocephalus caused by Aspergillus flavus.

C S Bryan, A F DiSalvo, L J Huffman

    Southern Medical Journal
    |December 1, 1980
    PubMed
    Summary
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    A new immunofluorescent staining technique diagnosed fungal infection, aspergillosis, in a patient with hydrocephalus linked to drug abuse. This case highlights central nervous system aspergillosis in parenteral drug users.

    Area of Science:

    • Medical Mycology
    • Neurology
    • Infectious Diseases

    Background:

    • Parenteral drug abuse is a risk factor for various infections.
    • Central nervous system (CNS) infections can present with diverse neurological symptoms.
    • Hydrocephalus and arachnoiditis are serious neurological conditions.

    Observation:

    • A patient with a history of parenteral drug abuse presented with communicating hydrocephalus and lumbar spinal cord arachnoiditis.
    • The patient's condition was suspected to be infectious in origin.
    • Diagnostic challenges in identifying specific pathogens in CNS infections.

    Findings:

    • A novel immunofluorescent staining procedure was utilized for diagnosis.
    • Aspergillosis was identified as the causative agent.

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  • Subsequent culture confirmed the diagnosis of fungal infection.

    • Implications:

    • The study introduces a new diagnostic method for fungal CNS infections.
    • It underscores the importance of considering aspergillosis in parenteral drug users with neurological symptoms.
    • The findings contribute to understanding the spectrum of CNS aspergillosis in this patient population.