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Related Experiment Videos

Experimental otitis media in chinchillas.

D M Lewis, J L Schram, S J Meadema

    The Annals of Otology, Rhinology & Laryngology. Supplement
    |May 1, 1980
    PubMed
    Summary

    Chinchillas develop resistance to pneumococcal otitis media after infection. This immunity relies on local immune responses in the middle ear, not systemic ones, and can be blocked by antibiotics.

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    Area of Science:

    • Immunology
    • Otolaryngology
    • Microbiology

    Background:

    • Otitis media is a common infection, often caused by Streptococcus pneumoniae.
    • Understanding immunity to otitis media is crucial for developing effective treatments and prevention strategies.

    Purpose of the Study:

    • To investigate the immune mechanisms underlying resistance to pneumococcal otitis media in chinchillas.
    • To determine if local or systemic immunity is primarily responsible for protection against reinfection.

    Main Methods:

    • Inducing otitis media in chinchillas via Streptococcus pneumoniae injection.
    • Assessing resistance to reinfection after primary infection and various immunization routes.
    • Analyzing antibody presence in middle ear effusions and serum.
    • Evaluating the impact of ampicillin treatment on resistance development.

    Main Results:

    • Recovery from primary infection conferred resistance to reinfection with Streptococcus pneumoniae.
    • Antibodies to pneumococcal polysaccharide were found in middle ear effusions but not serum.
    • Direct middle ear immunization induced resistance, while intramuscular or intranasal routes did not.
    • Ampicillin treatment of primary infections blocked the development of resistance.

    Conclusions:

    • Chinchillas develop immunity to pneumococcal otitis media following recovery from infection.
    • This immunity is primarily mediated by local immune mechanisms within the middle ear.
    • Systemic immunization or antibiotic treatment can impair the development of protective immunity.

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