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[Salmonella sensitivity to antibiotics]
Abstract:
Antibiotic sensitivity of 142 strains of Salmonella isolated from patients within 1974-1976 was studied. An increase in the number of the pathogenic microbes resistant to streptomycin was noted. Rare isolates highly resistant to ampicillin were registered. The number of Salmonella sensitive to other antibiotics did not practically change. Levomycetin proved to be a rather active drug in vitro. Still, its use in therapy of salmonelleses did not always produce positive results. The use of levomycetin in clinics is expedient only after careful and repeated estimation of antibioticograms.
Insights
Antibiotic resistance in Salmonella increased, particularly to streptomycin and ampicillin, between 1974-1976. While Levomycetin showed in vitro activity, clinical efficacy varied, necessitating antibioticogram testing before treatment.
Area of Science:
- Microbiology
- Infectious Diseases
- Pharmacology
Context:
- Analysis of 142 Salmonella strains isolated from patients between 1974 and 1976.
- Focus on antibiotic sensitivity patterns over a two-year period.
Purpose:
- To investigate the evolving antibiotic sensitivity profiles of Salmonella.
- To identify trends in resistance to key antibiotics like streptomycin and ampicillin.
- To evaluate the clinical utility of Levomycetin for salmonellosis.
Summary:
- A notable increase in streptomycin-resistant Salmonella strains was observed.
- Rare isolates exhibited high-level ampicillin resistance.
- Salmonella sensitivity to most other tested antibiotics remained stable.
- Levomycetin demonstrated in vitro effectiveness but inconsistent clinical outcomes.
- Repeated antibioticogram assessment is crucial for guiding Levomycetin therapy.
Impact:
- Highlights the emergence of antibiotic resistance in Salmonella during the mid-1970s.
- Underscores the importance of susceptibility testing for guiding antimicrobial therapy.
- Provides historical data on antibiotic resistance trends relevant to public health surveillance.